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It has been demonstrated that addressing the deficit in synaptic plasticity caused by neuronal atrophy and cell death can be beneficial in the treatment of depression (Popa et al., 2010)

Metformin triggers apoptosis and induction of the G0/G1 switch 2 gene in macrophages

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[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Whiteman M., Armstrong J.S., Chu S.H., Jia-Ling S., Wong B.S., Cheung N.S., Halliwell B., Moore P.K

The MRI images above illustrates the side view of the spine, on the left hand side, and the corresponding cross-section, on the right hand side